When ESC made it possible to open multiple quotes, invoices, etc., etc. it made a lot of processes easier. However, if you have to copy from one screen to another it can still be a bit clunky.
So, my tip is that ESC will allow you to open multiple instances of the program on one computer. If you have multiple monitors it makes it simple to compare two items, move things back and forth, etc. However, you do have to maintain awareness of which reports or dialog boxes come from which instance of ESC, or you're going to get some surprises.
Hope this helps.